[The molecular markers related to personalized therapy of non-small cell lung cancer].
نویسندگان
چکیده
The Molecular Markers Related to Personalized Therapy of Non-small Cell Lung Cancer Nannan GUO, Chengze YU, Changhai YU Department of Thraco-cardiac Surgery, the First Hospital Affiliated to General Hospital of the Chinese People's Liberation Army, Beijing 100048, China; Department of General Surgery, 307 Hospital of Academy of Military Medical Sciences, Beijing 100850, China Corresponding author: Chengze YU, E-mail: [email protected] DOI: 10.3779/j.issn.1009-3419.2011.03.17
منابع مشابه
Expression of Two Basic mRNA Biomarkers in Peripheral Blood of Patients with Non-Small Cell Lung Cancer Detected by Real-Time RT-PCR, Individually and Simultaneously
Introduction: Although extensive research has been conducted on lung cancer markers, a singular clinically applicable marker has not been found yet. The objective of this study was to evaluate the sensitivity and the specificity of carcinoembryonic antigen (CEA) mRNA and lung-specific X protein (LUNX) mRNA biomarkers in peripheral blood to detect lung cancer individually and simultaneously. Met...
متن کاملمقایسه تغییرات نشانگرهای زیستی آنتی ژن کارسینوژن جنینی ، قطعه محلول سیتوکراتین 19 و آنزیم تلومراز در نمونه های بیماران مبتلا به سرطان یاخته های کوچک و غیر کوچک ریه
Introduction & Objective: The roles of tumor markers in the prognosis and diagnosis of lung cancer is under investigation. The aim of this study was to examine correlation between serum levels of Carcinoembryonic Antigen (CEA) and Cyfra 21-1 with telomerase activity on biopsy samples in patients with lung cancer and controls. Materials & Methods: We studied 50 malignant lung cancer patients ...
متن کاملNon-Small Cell Lung Cancer
Downloa development of molecular markers is crucial for improving therapy in advanced non-small cell ancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, articular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, with p validation, and clinical application to different types of tissue specimens are discussed. Clin ...
متن کاملPreparation and in-vitro Evaluation of an Antisense-containing Cationic Liposome against Non-small Cell Lung Cancer: a Comparative Preparation Study
The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...
متن کاملIdentification of a Novel Tumor-Binding Peptide for Lung Cancer Through in-vitro Panning
Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Zhongguo fei ai za zhi = Chinese journal of lung cancer
دوره 14 3 شماره
صفحات -
تاریخ انتشار 2011